[68Ga]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
Status:
Not yet recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
Acute myocardial inflammation is an heterogenic syndrome involving different clinical
pathologies with different outcome. For the purpose of this study protocol, we focuse on
three entities of this syndrome, namely the acute cellular cardiac allograft rejection (ACR),
cardiac sarcoidosis (CS) and the immune checkpoint inhibitor induced myocarditis (ICIM), for
which non-invasive diagnosis remains challenging.
Since accurate diagnosis of myocardial inflammation in an early stage is crucial, this study
aims to investigate the accuracy of [68Ga]Ga-PentixaFor as a marker of for the presence of
inflammatory cells (T-lymphocytes and M1) in described patients.
The identification of a correlation between [68Ga]Ga-PentixaFor myocardial accumulation with
currently accepted diagnostic tools would open up new ways to non-invasively diagnose acute
myocardial inflammation.